Synthesis of Gefinitib

D'Souza, N., Castañer, J., Levin, M., Iressa. Drugs Fut 2002, 27, 4, 339.

Gibson K.H., Quinazoline derivs.. EP 0823900; JP 1999504033; US 5770599; WO 9633980 .

Gibson K.H., Grundy W., Barker A.J. et al.; Studies leading to the identification of ZD1839 (Iressa): An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Bioorg Med Chem Lett 2001, 11, 14, 1911.

Molecules 2006, 11, 286-297



Synthesis of Gefitinib from Methyl 3-Hydroxy-4-methoxy-benzoate