Synthesis of Lapatinib

Guntrip S.B., Lackey K.E., Cockerill G.S., Carter M.C., Smith K.J. Bicyclic heteroaromatic compounpds as protein tyrosine kinase inhibitors. EP 1047694; WO 9935146 .

Quinazoline ditosylate salt compounds  (US7157466)

A NOVEL PROCESS FOR THE PREPARATION OF LAPATINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS (WO 2010061400)