Tandutinib

Name	4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide;
СAS	387867-13-2
Formula	C31H42N6O4
MW	562.70
Synonim	CT53518, MLN518 ,  4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide;  (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide
Smile	COc4cc3c(N2CCN(C(=O)Nc1ccc(OC(C)C)cc1)CC2)ncnc3cc4OCCCN5CCCCC5
Logp	4.629
TPSA	92.3
URL	http://ak-tki.blogspot.com/2011/01/synthesis-of-tandutinib.html - synthesis of tandutinib
A piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing.
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