Tyrosine Kinase Inhibitors: Icotinib


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CAS	610798-31-7
Formula	C₂₂H₂₁N₃O₄
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Icotinib (BPI-2009H), a highly selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI), in two EGFR-mutated lung cancer cell lines compared to A549, a cell line without EGFR mutations. Icotinib blocked EGFR-mediated intracellular tyrosine phosphorylation (IC50 = 45 nM) in the human epidermoid carcinoma A431 cell line and inhibits tumor cell proliferation.
Икотиниб (BPI-2009H), высокоселективный ингибитор рецептора эпидермального фактора роста (EGFR ИТК), в двух линий EGFR-мутированного рака легких
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