Ibrutinib

Ibrutinib (IMBRUVICA, by Pharmacyclics, Inc. ) is an inhibitor of Bruton’s tyrosine kinase (BTK). The chemical name is 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one

C25H24N6O2
MW 440.50

Ibrutinib is a white to off-white solid, freely soluble in DMSO, soluble in МеОН and practically insoluble in Н2О.

Synthesis of ibrutinib

04_dec_2013