Flumatinib

Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, Issue 17, 2010
Synthesis, Crystal Structure, and Spectral Characterization of Flumatinib Mesylate
DOI:    10.1080/00397910903289248
Gang Xu, Hong Shen, Taifeng Tong, Aifeng Lu and Shaohua Gou

Apatinib

Targets: VEGFR

Apatinib was first synthesized by Advenchen Laboratories in California, USA and is being developed by Jiangsu Hengrui Medicine (China), LSK BioPartners (US) and Bukwang Pharmaceutical Company (Korea)

Synthesis os apatinib 

US7129252

"Six membered amino-amide derivatives an angiogenisis inhibitors" 

28 february 2013