Apatinib

Targets: VEGFR

Apatinib was first synthesized by Advenchen Laboratories in California, USA and is being developed by Jiangsu Hengrui Medicine (China), LSK BioPartners (US) and Bukwang Pharmaceutical Company (Korea)

Synthesis os apatinib 

US7129252

"Six membered amino-amide derivatives an angiogenisis inhibitors" 

28 february 2013