Synthesis of key intermediate
Sun, L.; Liang, C; Shirazian, S.; Zhou, Y.; Miller, T.; Cui, J.; Fukuda, J. Y.; Chu, J.-Y.; Nematalla, A.; Wang, X.; Chen, H.; Sistla, A.; Luu, T. C; Tang, F.; Wei, J.; Tang C. J. Med. Chem. 2003, 46, 1116-1119
Tang, P. C; Miller, T.; Li, X.; Sun, L.; Wei, C. C; Shirazian, S.; Liang, C; Vojkovsky, T.; Nematalla, A. S.; WO 01/060814,2001.
First metod
Manley, J. M.; Kaiman, M. J.; Conway, B. G.; Ball, C. C; Havens, J. L.;
Vaidyanathan, R. J. Org. Chem. 2003, 68, 6447-6450.
Vaidyanathan, R. In Process Chemistry in the Pharmaceutical Industry, Ed.
Braish, T. and Gadamasetti, K. CRC Press, Boca Raton, Fl, 2008, 49-63.
Havens, J. L.; Vaidyanathan, R. U.S. Pat. 06/0009510, 2006.
Sun, L.; Liang, C; Shirazian, S.; Zhou, Y.; Miller, T.; Cui, J.; Fukuda, J. Y.; Chu, J.-Y.; Nematalla, A.; Wang, X.; Chen, H.; Sistla, A.; Luu, T. C; Tang, F.; Wei, J.; Tang C. J. Med. Chem. 2003, 46, 1116-1119
Tang, P. C; Miller, T.; Li, X.; Sun, L.; Wei, C. C; Shirazian, S.; Liang, C; Vojkovsky, T.; Nematalla, A. S.; WO 01/060814,2001.
First metod
Other methods
Manley, J. M.; Kaiman, M. J.; Conway, B. G.; Ball, C. C; Havens, J. L.;
Vaidyanathan, R. J. Org. Chem. 2003, 68, 6447-6450.
Vaidyanathan, R. In Process Chemistry in the Pharmaceutical Industry, Ed.
Braish, T. and Gadamasetti, K. CRC Press, Boca Raton, Fl, 2008, 49-63.
Havens, J. L.; Vaidyanathan, R. U.S. Pat. 06/0009510, 2006.
An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals
Beilstein J. Org. Chem. 2011, 7, 442–495.
Beilstein J. Org. Chem. 2011, 7, 442–495.
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